218697
Casein Kinase II Inhibitor I
TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
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25 May 2012
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A cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC50 < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC50 = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218708) in DMSO, is also available.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | CK2 rat liver, human recombinant | ||
| Primary Target IC50 | 900 nM , 1.6 µM | ||
| Secondary target | DYRK (IC50 > 1 µM for DYRK1a), WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively) | ||
| Molar mass | 434.7 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥99% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C6HBr4N3 | ||
| CAS number | 17374-26-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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