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EMD Millipore
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26 May 2013
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A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Molar mass | 309.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C13H12FN3O3S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Regulatory Review |
||
