203850  Bromocriptine Mesylate

2-Bromo-α-ergocryptine, Methanesulfonate, BRC, BCT

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18 April 2014

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This product has been discontinued.

We apologize for the inconvenience, but we do not currently have an alternative product. For related products, please refer to our complete listing of nitric oxide synthase inhibitors.

Dopamine D2 receptor agonist that potently and selectively inhibits neuronal NOS (nNOS; IC50 = 10 µM) by affecting the activation of NOS by calmodulin. Has only a weak inhibitory effect on inducible NOS (iNOS; IC50 > 100 µM). Modulates P-glycoprotein function. Inhibits Mg2+ ATPase activity (IC50 = 300 nM) and verapamil-induced P-glycoprotein ATPase activity (Ki = 200 nM). Also inhibits prolactin secretion.
Product information
Form Pale yellow powder
Primary Target nNOS
Primary Target IC50 10 µM
Secondary target iNOS > 100 µM
Molar mass 750.7
Hygrocopic Yes
Purity ≥98% by TLC
Solubility CHCl3:MeOH (1:1)
Chemical formula C32H40BrN5O5 · CH3SO3H
RTECS KE1595000
CAS number 22260-51-1
Merck USA index 14, 1416
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic
Safety information
S Phrase S: 36

Wear suitable protective clothing.
R Phrase R: 62

Possible risk of impaired fertility.
Bromocriptine Mesylate, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


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