219330
β-Catenin/Tcf Inhibitor, FH535
N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide, Wnt Pathway Inhibitor IX
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EMD Millipore
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25 May 2012
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A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Molar mass | 361.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥94% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C13H10Cl2N2O4S | ||
| CAS number | 108409-83-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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