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EMD Millipore
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United States
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25 May 2012
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A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 350.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by TLC | ||
| Solubility | DMSO | ||
| Chemical formula | C20H30O5 | ||
| RTECS | LU3490750 | ||
| CAS number | 5508-58-7 | ||
| Merck USA index | 14, 633 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
