126870
Alsterpaullone
9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
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EMD Millipore
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25 May 2012
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A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC50 = 4 nM) and Cdk1/cyclin B (IC50 = 35 nM). Displays remarkable in vitro antitumor activity. Inhibits Tau phosphorylation at sites that are typically phosphorylated by GSK-3β in Alzheimer’s disease. Also inhibits Cdk5/p25-dependent phosphorylation of DARPP-32.
| Product information | |||
|---|---|---|---|
| Form | Brown solid | ||
| Primary Target | Cdkl/Gsk-3β | ||
| Primary Target IC50 | 35 nM/4 nM | ||
| Secondary target | HCT-116 (IC50 in the nM range) | ||
| Molar mass | 293.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C16H11N3O3 | ||
| CAS number | 237430-03-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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