126871
Alsterpaullone, 2-Cyanoethyl
3-(6-Oxo-9-nitro-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepin-2-yl)propionitrile
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25 May 2012
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A cell-permeable and reversible Alsterpaullone (Cat. No. 126870) derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 µM). Displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). Shown to inhibit other kinases in a commercially available testing screen panel (pIC50 = −logIC50[M]; pIC50 = ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 µM).
| Product information | |||
|---|---|---|---|
| Form | Light orange solid | ||
| Primary Target | Cdkl/Gsk-3β, Cyclin B | ||
| Primary Target IC50 | 230 pM/800 pM | ||
| Secondary target | Cdk5/p25 (IC50 = 30 nM) | ||
| Molar mass | 346.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C19H14N4O3 | ||
| CAS number | 852529-97-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |
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