126855
Alendronate, Sodium Salt
Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
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EMD Millipore
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25 May 2012
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An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Molar mass | 325.1 | ||
| Hygrocopic | Yes | ||
| Purity | ≥98% by titration | ||
| Solubility | H2O | ||
| Chemical formula | C4H12NNaO7P2 • 3H2O | ||
| RTECS | SZ6523500 | ||
| CAS number | 121268-17-5 | ||
| Merck USA index | 14, 229 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
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| Safety information | |||
|---|---|---|---|
| R Phrase |
R: 22; |
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