658395
AG 18
α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
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EMD Millipore
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23 May 2012
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A broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | epidermal growth factor receptor autophosphorylation | ||
| Primary Target IC50 | 40 mM | ||
| Secondary target | the GTPase activity of transducin (IC50 = 10 mM), aldosterone secretion in response to Angiotensin II | ||
| Molar mass | 186.2 | ||
| Protect from Light | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | Acetic acid, DMSO, or EtOH | ||
| Chemical formula | C10H6N2O2 | ||
| CAS number | 118409-57-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
