104551
ACC2 Inhibitor, CD-017-0191
2-((2-(4-isopropoxyphenyl)-5-methyloxazol-4-yl)methylthio)oxazolo[4,5-b]pyridine
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25 May 2012
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A cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC50 = 2.8 µM), which does not inhibit human ACC1 at all at concentrations up to 100 µM, in vitro. It is also shown to inhibit the growth of yeast (IC50 = 3.8 µM), in which the native ACC1 gene is replaced with the human ACC2 strain; but not with the human ACC1 strain at concentrations ≤ 100 µM. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µM.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 381.45 | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C20H19N3O3S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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