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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A cell-permeable, reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC50 = 710 nM) vs. iNOS (IC50 = 20 µM). Also inhibits bovine endothelial nitric oxide synthase (IC50 = 800 nM). Binds to the heme group of NOS.
| Alternatives | |
|---|---|
| 484500 | 7-Nitroindazole, Sodium Salt |
| Alternative products for 7-Nitroindazole | |
| 484500 | 7-Nitroindazole, Sodium Salt |
| Accessories for 7-Nitroindazole |
| Product information | |||
|---|---|---|---|
| Form | Yellowish brown solid | ||
| Primary Target | NOS | ||
| Primary Target IC50 | 710 nM | ||
| Secondary target | iNOS (IC50 = 20 mM) endothelial nitric oxide synthase (IC50 = 800 nM) | ||
| Molar mass | 163.1 | ||
| Cell permeable | Yes | ||
| Reversible | Yes | ||
| Purity | ≥97% by TLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C7H5N3O2 | ||
| RTECS | NK7962200 | ||
| CAS number | 2942-42-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 53-22-36/37/39-45 Avoid exposure - obtain special instructions before use. Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 40-60 Limited evidence of a carcinogenic effect. May impair fertility. |
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