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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | protein carboxymethyltranferase | ||
| Secondary target | FGF-2receptor tyrosine kinase activity | ||
| Molar mass | 297.3 | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥99% by HPLC | ||
| Solubility | DMF or DMSO | ||
| Chemical formula | C11H15N5O3S | ||
| RTECS | AU7410000 | ||
| CAS number | 2457-80-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Irritant |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
||
| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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