287891
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
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25 May 2012
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A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | casein kinase II | ||
| Primary Target IC50 | 6 µM | ||
| Molar mass | 319.2 | ||
| Purity | ≥98% by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C12H12Cl2N2O4 | ||
| RTECS | DD7310000 | ||
| CAS number | 53-85-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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