Information
X


EMD Chemicals

more less

Eshmuno® A resin

Eshmuno® A resin

Protein A Affinity Chromatography resin with an “AAA-rating”

Eshmuno® A is a rigid, high capacity Protein A affinity chromatography resin for the purification of Fc-containing proteins, including but not limited to monoclonal antibodies. Eshmuno® A resin can be cleaned and sanitized under acid and alkaline conditions while maintaining high dynamic binding capacity at high flow rates.

Proven Technology
The Eshmuno® A resin contains a EMD Millipore proprietary ligand. This ligand is recombinantely expressed in E. coli. No animal derived products are used during production. The Eshmuno® A resin is synthesized via immobilization of the ligand on to the Eshmuno® base matrix, which is a rigid and hydrophilic polymer based on polyvinylether.

Eshmuno® A resin earns an "AAA rating" for its –
Eshmuno A Resin
  • Acid resistance
  • Alkaline resistance
  • Aggregate removal

Eshmuno® A resin further exhibits excellent –

  • Productivity: high binding capacity, superior flow capability, reusability, and low cost of goods (COGS)
  • Product purity: increased aggregate removal, excellent HCP reduction, low leached Protein A, consistent viral clearance, and reduced Fab binding
  • Scalability: linear scale-up
  • Reliability: batch-to-batch consistency, GMP manufacturing environment, and continuous regulatory support

High Binding Capacity
Optimizing the particle and pore size of the Eshmuno® base matrix along with the immobilization of the EMD Millipore proprietary ligand enables a significant increase in dynamic binding capacity. Eshmuno® A resin shows higher dynamic binding capacity than other commercially available media. The sharp breakthrough curve allows for higher loading of Fc-containing protein to be purified, thereby maximizing column throughput.

 

The breakthrough curves of various commercially available Protein A media at 3 minutes residence time

Graphic legend: The breakthrough curves of various commercially available Protein A media at 3 minutes residence time

 

 

 

 

 

High Productivity
The combination of optimized particle size and high dynamic binding capacity at high flow rate translates into high productivity of Eshmuno® A media.

Dynamic Binding Capacity (mAb feed)

Graphic legend: Dynamic Binding Capacity (mAb feed)

© Merck KGaA, Darmstadt, Germany, 2014

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


x

Welcome to EMD Millipore

 

Europe, Middle East and Africa Asia / Pacific North America, Central America and the Carribean South America

Please select your country:

North America, Central America and the Carribean

South America

Europe, Middle East and Africa

Asia / Pacific

All countries from A to Z

If you can't find your country please click here.

 

x

EMD Millipore Chemicals Cart ()

You are entering the Millipore online shop. Both carts are maintained for you while you shop between sites. We recommend to complete your Merck order before visiting Millipore.com.

Go to Millipore Proceed to checkout


What kind of products are you looking for?

Millipore

Bio manufacturing and Life science.

EMD Millipore Chemicals

High-quality industrial and laboratory chemicals.


Important message


It is currently not possible to order Bioscience products together with other EMD products. We recommend completing your current order first.

Do you wish to proceed without completing your current order? If so, this will empty your shopping cart.