Chromolith^® HPLC Columns

High speed, high performance in monolithic form

Chromatographers today seek ways to analyse more samples – by speeding up the separation process, and therefore analysis. EMD’s Chromolith^® HPLC Columns provide excellent separations in a fraction of the time taken by standard 5 μm particulate columns, at half the column back pressure.

Typical particulate HPLC columns are filled with silica particles of 3 or 5 microns. Despite its high separation performance, such small particle size limits the speed of analysis and column length, plus reduces column lifetime from blockages and the lifetime of HPLC instrument and injector seals at high pressure.

Benefits at a glance

Up to 9 times the speed of separations at much lower column back pressure compared particulate columns  Significantly increased column lifetime Column length no longer pressure limited Well suited for standard HPLC instruments

Chromolith^® HPLC Columns from EMD, however, are not filled with minute silica particles like conventional packed HPLC columns, but consist of a single rod of high purity monolithic silica with a revolutionary bimodal pore structure. Its macropores dramatically reduce the column back pressure to enable faster flow rates, thereby considerably reducing the analysis time. While mesopores form the fine porous structure, and provide a large active surface area for highly efficient separations.

A winning innovation

Winner of numerous awards including one of the five most important innovations of 2001, EMD’s Chromolith^® HPLC Columns are constantly finding new applications in every area of pharmaceutical and biological research, plus food, chemical and environmental analysis.
Recent examples include analysis of illicit drugs in just half the time of conventional methods, and analysis of pollutant phenols in just three minutes – which previously took 18.

With longer lifetime, less matrix sensitivity with biological samples, and the possibility of coupling multiple columns together for efficiencies of 100.000 plates at normal pressure, EMD Chromolith^® HPLC Columns offer speed and performance previously unseen in monolithic form.

If you would like further information, see also our brochure on Chromolith^® HPLC Columns or please contact us.