129876
Amiloride, Hydrochloride
Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
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EMD Millipore
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01821 Billerica, MA
United States
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18 May 2013
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An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
| Product information | |||
|---|---|---|---|
| Form | Off-white to yellow solid | ||
| Primary Target | capillary morphogenesis | ||
| Primary Target IC50 | 130 µM | ||
| Molar mass | 302.1 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Reversible | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or H2O | ||
| Chemical formula | C6H8ClN7O . HCl•2H2O | ||
| RTECS | UQ2275500 | ||
| CAS number | 2016-88-8 | ||
| Merck USA index | 14, 406 | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 45-36 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Wear suitable protective clothing. |
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| R Phrase |
R: 25 Toxic if swallowed. |
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