692000
ZM 336372
N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
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24 May 2012
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A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | protein kinase c-Raf | ||
| Primary Target IC50 | 70 nM | ||
| Secondary target | SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM) | ||
| Molar mass | 389.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C23H23N3O3 | ||
| CAS number | 208260-29-1 | ||
| Declaration | Sold under license of PCT Application W098/22,103. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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