559388
SB 202190
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI
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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
24 May 2012
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A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.
| Alternatives | |
|---|---|
| 559393 | SB 202190, Hydrochloride |
| Alternative products for SB 202190 | |
| 559393 | SB 202190, Hydrochloride |
| Accessories for SB 202190 |
| Product information | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Primary Target | p38β | ||
| Primary Target IC50 | 16 nM | ||
| Secondary target | ATF-2 (IC50 = 280 nM) | ||
| Molar mass | 331.3 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C20H14FN3O | ||
| CAS number | 152121-30-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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