370655
PKG Iα Inhibitor, Cell-Permeable
DT-3, RQIKIWFQNRRMKWKKLRKKKKKH, cGMP-dependent Protein Kinase Iα Inhibitor, Cell Permeable, cGPK Iα Inhibitor, Cell Permeable, Protein Kinase G Iα Inhibitor
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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
24 May 2012
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A highly potent, reversible, and substrate competitive membrane-permeable Drosophila Antennapedia homeodomain fused-peptide that selectively inhibits protein kinase G Iα (Ki = 25 nM). Shown to efficiently translocate into arterial smooth muscle cells and inhibit NO-induced vasodilation (ED50 = 47 µM). Inhibits protein kinase A at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH | ||
| Form | Lyophilized | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | PKG1α | ||
| Primary Target Ki | 25 nM | ||
| Secondary target | protein kinase A (Ki = 493 µM) | ||
| Molar mass | 3294.1 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C152H258N52O28S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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