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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
24 May 2012
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A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | CaM kinase II | ||
| Primary Target Ki | 1.8 nM | ||
| Secondary target | mlck (Ki = 17 nM), PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). (IC50 = 3 nM) of the protein tyrosine kinase activity of the NGF receptor gp140trk | ||
| Molar mass | 467.5 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMF or DMSO | ||
| Chemical formula | C27H21N3O5 | ||
| RTECS | NZ0550000 | ||
| CAS number | 97161-97-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
