EMD Millipore Webinars

Upcoming Webinars


Biopharmaceutical Manufacturing and Small Molecule Pharmaceuticals

Perfusion-Based Bioproduction Applications Using Mobius® CellReady Bioreactors

  • Presenter: Michael Cunningham, Process Development Scientist, EMD Millipore
  • Date: Thursday, November 6, 2014
  • Duration: 1 Hour
  • Session: 5:00 PM CET
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Abstract:
Manufacturing of biotherapeutics is evolving to encompass widespread use of single-use technologies in order to control costs and optimize operational flexibility. Single-use bioreactors are commonly used for both process development and commercial production of monoclonal antibodies (mAbs) and recombinant proteins. While utilization of these systems have routinely employed batch and fed-batch modes of operation generate recombinant products from mammalian expression systems, the use of the Mobius® Cellready bioreactor for perfusion in this operational space has yet to be sufficiently characterized and implemented.

During this webinar, you will see the results of a recent study evaluating the use of the Mobius® Cellready bioreactor connected to Alternating Tangential Flow devices for perfusion.


Compacted Media - Improving Solubility and Stability

  • Topic: In this webinar, we will present data underlining the advantages of compacted media and the stability of raw materials using UPLC and LC-MS methods completed with results from fed-batch cultivation experiments based on compacted cell culture media.
  • Presenter: Nikolai Stankiewicz, Head of Technology Transfer Laboratory, EMD Millipore
  • Date: Thursday, November 13, 2014
  • Duration: 1 Hour
  • Session 1: 10:00 AM CET
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  • Session 2: 4:00 PM CET
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Abstract:
Dry powder cell culture media formulations provide many advantages with respect to shipping and storage. However to leverage these benefits, they need to be highly soluble, homogeneous and convenient to handle. An improvement of dry powder media properties can be achieved by the combination of optimized milling procedures and suitable formulation technologies. Starting from a homogeneous dry powder medium, the roller compaction technology is able to fix this homogeneity in larger compactate particles (> 1000 µm) so that de-mixing can be excluded. Additionally, the presented roller compaction offers several other advantages, specifically product stability, based on the fact that only pressure and no water is needed in the production process. Applying media as compactates also reduces dust formation and improves the flowability, making the handling of these cell culture media much more convenient. But the key advancement of using compacted media is the acceleration of the dissolution speed. In this webinar, we will present data underlining the advantages of compacted media and the stability of raw materials using UPLC and LC-MS methods completed with results from fed-batch cultivation experiments based on compacted cell culture media.

Industrial Microbiology

New EN ISO 11133 - Quality Assured Culture Media for Food and Water Testing

  • Topic: Informative webinar on new EN ISO 11133 which is now a full standard and as such mandatory
    Note: webinar pertains to European ISO standards
  • Presenter: Barbara Gerten, Application Training Scientist at EMD Millipore and a member of the ISO committee for microbiological standards regarding food and water testing
  • Date: Wednesday, November 12, 2014, 10:00 AM CET 
  • Duration: 1 Hour

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Abstract:
The International Organization for Standardization recently published the revised EN ISO 11133, which is now a full standard and as such mandatory for all accredited laboratories that perform microbiological testing of food, animal feed or water using culture media. It has been completely restructured, clarifying procedures and drawing a clear line between the responsibilities of the laboratories and the manufacturers of culture media regarding media preparation, production, storage and performance testing

Life Science Research

Goodbye, Bradford Assays! Discover Infrared-Based Protein Quantitation Using the Direct Detect® Spectrometer

  • Topic: Beginner-level demonstration video shows you exactly how to set up the Direct Detect® system so that you still measure protein concentrations accurately.
  • Presenter: Katherine Ruby, Ph.D., Protein Specialist, EMD Millipore
  • Date: Thursday, October 23, 2014
  • Time: 1:00 PM Eastern Daylight Time
  • Duration: 1 hour

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Abstract:

Analyzing protein using infrared (IR) spectrometry is a decades-old technique, and is known to be an accurate, information-rich alternative to other assays for total protein. Now, anyone, even without spectroscopy training, can exploit IR-based protein quantitation for even complex biological samples, using the new Direct Detect® spectrometer.

 



Novel Multiplexed Assay Panels to Detect Kidney Injury Biomarkers in Mouse Models

  • Topic: The use novel multiplexed assay panels have recently been used to detect kidney injury biomarkers in small volumes of urine and serum. Understand how to develop informative and predictive experimental models of kidney injury. The application of these kidney injury biomarkers to drug development will accelerate the advancement of effective and safe new drugs to market.
  • Presenter: Dr. Mitch McGill, postdoctoral fellow in the laboratory of Hartmut Jaeschke at the University of Kansas Medical Center; and Dr. Venkata Sabbisetti, Instructor in Renal Division at Brigham and Women’s Hospital/Harvard Medical School
  • Date: Tuesday, November 4, 2014
  • Time: 12pm – 1pm EST (09:00-10:00 PST; 17:00-18:00 GMT; 18:00-19:00 CET)

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Abstract:

The kidney is a major site of organ damage caused by drug toxicity. Over the past decade, several novel kidney injury biomarkers have been identified and validated in rat models, but there has been a lack of reliable assays to quantitatively assess these biomarkers in mouse models, which are more widely used than rat in the drug development process. This 1-hour webinar will describe some of the major laboratory methods, particularly bead-based assays, employing biomarkers to study toxicity resulting from organ injury.

 



A Closer Look at Cell Death with Imaging Flow Cytometry

  • Presenters: Irene La-Beck, Pharm.D., Texas Tech University Health Sciences Center; Sabine Pietkiewicz, Ph.D., Otto von Guericke University, Germany; and Haley R. Pugsley, Ph.D., EMD Millipore
  • Date: Wednesday, November 5, 2014
  • Time: 9AM PST, 12PM EST, 5PM GMT, 6PM CET

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Abstract:

Apoptosis, necrosis, and autophagy are all different forms of programmed cell death (PCD) and are essential for regulating homeostasis and eliminating undesirable cells. Distinguishing between different forms of PCD can be challenging because these processes depend upon changes in morphology and subcellular structure that are often masked in studies of heterogeneous cell populations. The use of imaging flow cytometry has been a method to overcome this problem and has led to new discoveries in the field of PCD.