The Clarisolve® mPAA polymer is a stimulus-responsive flocculation polymer designed specifically to enable a simpler clarification of high density cell culture monoclonal antibody (mAb) processes. The Clarisolve® mPAA polymer helps minimize risk by providing low residual polymer levels with no negative impact on downstream unit operations, and is less dependent on the dosage of the polymer which increases robustness and results in a wide-dosing window.
Optimal flocculation results are delivered when used in a concentration of 0.1% and 0.5%. The stimulus-responsive nature of the polymer means lower residual polymer levels.
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