Eshmuno® S Resin

 
 

The Strong Cation Exchanger


For Downstream mAb Purification

Eshmuno® S is a strong cation exchange resin, designed for fast, efficient purification in direct capture of rec. proteins and post-protein A steps for mAbs. Eshmuno® S has a superior binding capacity compared to other modern cation-exchangers. With Eshmuno® S, you achieve superior productivity and maximum performance in your downstream purification of monoclonal antibodies.

Like all other Eshmuno® IEX family members, Eshmuno® S resin combines a tentacle structure for more effective binding of the target molecules with the advantages of an innovative hydrophilic polyvinyl ether base matrix. This combination allows the use of much higher flow rates while the biomolecule is still strongly bound by the tentacle.

Eshmuno® S resin provides:
  • Highly productive in direct capture of rec. proteins and post-protein A steps for mAbs.
  • Superior binding capacity
  • Excellent pressure-flow behavior

Outstanding performance
Based on a 85µm diameter base bead, Eshmuno® S exhibits a superior binding capacity combined with an excellent pressure flow behavior, resulting in outstanding productivity of more than 40 mg/ml per hour in downstream processing. As a result, you can save considerable manufacturing costs in your mAb production.

DBC of mAB03 5 mg/mL in buffer A, 2 min. residence time, 1 mL scout column
DBC of mAb03 5 mg/mL in buffer A, 2 min. residence time, 1 mL scout column



Pressure versus flow curve of Eshmuno® S resin

20 cm i.d. column; 19,5 cm bed height; 8% compression recorded in 150 mM NaCl
20 cm i.d. column; 19,5 cm bed height; 8% compression recorded in 150 mM NaCl

Efficient HCP removal
One advantage of using Eshmuno® S resin is its high selectivity for the biomolecule of interest. Eshmuno® S resin efficiently removes host cell proteins, resulting in greater purity compared to traditional chromatography resins.

 
 
Advancing Next Generation Bioprocessing

 

Webinar: High-throughput Process Development: Utilizing the Full Potential of Miniature Chromatography Columns - Watch Now

Webinar:
High-throughput Process Development: Utilizing the full potential of miniature chromatography columns

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Chromabolt® columns packed with Eshmuno® S resin

Chromabolt® Columns
packed with Eshmuno® S resin

Available Now!