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525145 | sPLA₂-IIA Inhibitor I - Calbiochem

525145
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₁H₅₀N₈O₆ · CF₃CO₂H

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      525145-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA2-IIA (human type IIA secreted phospholipase A2; IC50 = 12.8 μM). Shown to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA even at 10 μM concentration.
          Catalogue Number525145
          Brand Family Calbiochem®
          Synonymsc(2NapA)LS(2NapA)R, TFA
          References
          ReferencesChurch, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
          Chemical formulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetsPLA2-IIA (human type IIA secreted phospholipase A2
          Primary Target IC<sub>50</sub>12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide Sequencecyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          525145

          References

          Reference overview
          Church, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-August-2008 RFH
          Synonymsc(2NapA)LS(2NapA)R, TFA
          DescriptionA highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of human type IIA secreted phospholipase A2 (sPLA2-IIA) (IC50 = 12.8 µM). Reported to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 µM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA at 10 µM.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
          Peptide Sequencecyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesChurch, W.B., et al. 2001. J. Biol. Chem. 276, 33156.