506149 | p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

506149
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₂O₃S₂ 213261-59-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506149-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
          Catalogue Number506149
          Brand Family Calbiochem®
          SynonymsNSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
          References
          ReferencesGrinkevich, V., et al. 2005. Nat. Med. 11, 1136.
          Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
          Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
          Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
          Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.
          Product Information
          CAS number213261-59-7
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₁₄H₁₂O₃S₂
          Chemical formulaC₁₄H₁₂O₃S₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp53
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506149

          References

          Reference overview
          Grinkevich, V., et al. 2005. Nat. Med. 11, 1136.
          Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
          Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
          Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
          Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Interactive Pathway Calendar
          p53 Pathway Poster ( 386 KB )
          p53 Pathway Poster ( 386 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-August-2008 RFH
          SynonymsNSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
          DescriptionA cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
          FormCrystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number213261-59-7
          Chemical formulaC₁₄H₁₂O₃S₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (3 mg/ml) or Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesGrinkevich, V., et al. 2005. Nat. Med. 11, 1136.
          Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
          Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
          Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
          Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.