506158 | p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem

506158
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₈N₂O 1670-87-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506158-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
          Catalogue Number506158
          Brand Family Calbiochem®
          SynonymsIndole-5-carboxamide
          References
          ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.
          Product Information
          CAS number1670-87-7
          FormOff-white solid
          Hill FormulaC₉H₈N₂O
          Chemical formulaC₉H₈N₂O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506158

          References

          Reference overview
          Medicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.

          Brochure

          Title
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-March-2009 RFH
          SynonymsIndole-5-carboxamide
          DescriptionA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1670-87-7
          Chemical formulaC₉H₈N₂O
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml) or H2O (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.