506156 | p38 MAP Kinase Inhibitor V - CAS 271576-77-3 - Calbiochem

506156
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₀ClN₅ 271576-77-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506156-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1δ and p38α (IC50 = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo.
          Catalogue Number506156
          Brand Family Calbiochem®
          Synonyms4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine, SC-409
          References
          ReferencesMbalaviele, G., et al. 2006. J. Pharm. Exp. Ther. 317, 1044.
          Liu, Y.H., et al. 2005. J. Card. Fail. 11, 74.
          Yu, J.J., et al. 2003. J. Immunol. 171, 6112.
          Product Information
          CAS number271576-77-3
          ATP CompetitiveY
          FormLight yellow solid
          Hill FormulaC₁₉H₂₀ClN₅
          Chemical formulaC₁₉H₂₀ClN₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp38 MAP Kinase
          Primary Target IC<sub>50</sub>20 and 40 nM, against CK1δ and p38α, respectively
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506156

          References

          Reference overview
          Mbalaviele, G., et al. 2006. J. Pharm. Exp. Ther. 317, 1044.
          Liu, Y.H., et al. 2005. J. Card. Fail. 11, 74.
          Yu, J.J., et al. 2003. J. Immunol. 171, 6112.

          Brochure

          Title
          Biologics 35.1
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-March-2009 JSW
          Synonyms4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine, SC-409
          DescriptionA cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1δ and p38α (IC50 = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number271576-77-3
          Chemical formulaC₁₉H₂₀ClN₅
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesMbalaviele, G., et al. 2006. J. Pharm. Exp. Ther. 317, 1044.
          Liu, Y.H., et al. 2005. J. Card. Fail. 11, 74.
          Yu, J.J., et al. 2003. J. Immunol. 171, 6112.