19-134 | p38/SAPK2 Inhibitor (SB 202190)

19-134
1 mg  
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      Overview

      Replacement Information

      Key Specifications Table

      Uni Prot Number
      Q15759
      Description
      Catalogue Number19-134
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionp38/SAPK2 Inhibitor (SB 202190)
      References
      Product Information
      PresentationC20H14FN3O
      Applications
      ApplicationThe p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.
      Key Applications
      • Kinase Assay
      Application NotesPotent inhibitor of p38 alpha/SAPK2a and p38 beta/SAPK2b kinases.
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
      Gene Symbol
      • MAPK11
      • p38-2
      • p38b
      • P38B
      • p38Beta
      • p38beta2
      • SAPK2B
      • SAPK2
      • PRKM11
      • P38BETA2
      Protein Targetp38/SAPK2
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
      COFACTOR: Magnesium (By similarity).
      SIZE: 364 amino acids; 41357 Da
      TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
      DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
      PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).
      SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in a kinase assay as an inhibitor.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions3 years at -20°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      p38/SAPK2 (SB202190) 2474848
      p38/SAPK2 (SB202190) 2719856
      p38/SAPK2 (SB202190) - 2273150 2273150
      p38/SAPK2 (SB202190) - DAM1655276 DAM1655276
      p38/SAPK2 (SB202190) - DAM1724065 DAM1724065
      p38/SAPK2 (SB202190) - DAM1739181 DAM1739181
      p38/SAPK2 (SB202190) - DAM1769203 DAM1769203
      p38/SAPK2 (SB202190) - DAM1776484 DAM1776484
      p38/SAPK2 (SB202190) - DAM1787899 DAM1787899
      p38/SAPK2 (SB202190) - JBC1864001 JBC1864001

      References

      Reference overviewApplicationPub Med ID
      The KDEL Receptor Modulates the Endoplasmic Reticulum Stress Response through Mitogen-activated Protein Kinase Signaling Cascades
      Yamamoto, K., et al
      J Biol Chem, 278:34525-32 (2003)  2003

      Kinase Assay12821650 12821650
      Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation
      Orr, A. W., et al
      J Biol Chem, 277:20453-60 (2002)  2002

      Kinase Assay11923291 11923291
      p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2.
      Kramer, R M, et al.
      J. Biol. Chem., 271: 27723-9 (1996)  1996

      Show Abstract
      8910365 8910365
      The primary structure of p38 gamma: a new member of p38 group of MAP kinases.
      Li, Z, et al.
      Biochem. Biophys. Res. Commun., 228: 334-40 (1996)  1996

      Show Abstract
      8920915 8920915
      A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
      Lee, J C, et al.
      Nature, 372: 739-46 (1994)  1994

      Show Abstract
      7997261 7997261