506101 p21-Activated Kinase Inhibitor, PAK18 - Calbiochem

506101
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄₆H₂₅₄N₅₈O₃₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506101-2MG
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      Stocked 
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          Plastic ampoule 2 mg
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          Description
          OverviewA PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).
          Catalogue Number506101
          Brand Family Calbiochem®
          SynonymsH₂N-RKKRRQRRR~G~PPVIAPRPEHTKSVYTRS-CO₂H, PAK Inhibitor I
          References
          ReferencesZhao, L., et al. 2006. Nat. Neurosci. 9, 234.
          Maruta, H., et al. 2002. Methods Mol. Biol. 189, 75.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as trifluoroacetate salt
          Hill FormulaC₁₄₆H₂₅₄N₅₈O₃₇
          Chemical formulaC₁₄₆H₂₅₄N₅₈O₃₇
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetPAK (p21-activated kinase)
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506101

          References

          Reference overview
          Zhao, L., et al. 2006. Nat. Neurosci. 9, 234.
          Maruta, H., et al. 2002. Methods Mol. Biol. 189, 75.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-August-2008 RFH
          SynonymsH₂N-RKKRRQRRR~G~PPVIAPRPEHTKSVYTRS-CO₂H, PAK Inhibitor I
          DescriptionA PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).
          FormLyophilized
          FormulationSupplied as trifluoroacetate salt
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄₆H₂₅₄N₅₈O₃₇
          Peptide SequenceH-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesZhao, L., et al. 2006. Nat. Neurosci. 9, 234.
          Maruta, H., et al. 2002. Methods Mol. Biol. 189, 75.