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4995 | Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem

4995
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₄₄O₁₂ · 8H₂O 11018-89-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      4995-1GM
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          Glass bottle 1 gm
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          Description
          OverviewInhibits Na+,K+-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G2 delay.
          Catalogue Number4995
          Brand Family Calbiochem®
          SynonymsStrophanthin G
          References
          ReferencesVerheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
          Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
          Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
          Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
          Xu, Z.J., et al. 1992. J. Physiol. 456, 405.
          Product Information
          CAS number11018-89-6
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₉H₄₄O₁₂ · 8H₂O
          Chemical formulaC₂₉H₄₄O₁₂ · 8H₂O
          ReversibleN
          Structure formula Image
          Applications
          ApplicationOuabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.
          Biological Information
          Primary TargetNa+,K+-ATPase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRN3850000
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          4995

          References

          Reference overview
          Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
          Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
          Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
          Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
          Xu, Z.J., et al. 1992. J. Physiol. 456, 405.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-January-2014 JSW
          SynonymsStrophanthin G
          DescriptionInhibits Na+ and K+-dependent ATPases. Has cardiotonic properties.
          FormWhite to off-white solid
          CAS number11018-89-6
          RTECSRN3850000
          Chemical formulaC₂₉H₄₄O₁₂ · 8H₂O
          Structure formula
          Purity≥95% by HPLC
          SolubilityHot H₂O (10 mg/ml). Not soluble in room temperature water.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
          Toxicity Toxic
          Merck USA index14 6901
          ReferencesVerheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
          Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
          Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
          Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
          Xu, Z.J., et al. 1992. J. Physiol. 456, 405.