516705 o-Phenanthroline - CAS 5144-89-8 - Calbiochem

516705
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₈N₂ · H₂O 5144-89-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      516705-500MG
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          Alu drum 500 mg
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          Description
          OverviewA metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a metalloprotease inhibitor. Inhibits glioma invasion in vitro.
          Catalogue Number516705
          Brand Family Calbiochem®
          Synonyms1,10-Phenanthroline Monohydrate
          References
          ReferencesStix, B., et al. 2001. Am. J. Pathol. 159, 561.
          Bolzan, A.D., et al. 2000. Mutat. Res. 447, 221.
          Wang, Y., et al. 1999. J. Biol. Chem. 274, 33043.
          Harayama, T., et al. 1999. Jpn. J. Can. Res. 90, 942.
          Krane, S.M., et al. 1996. J. Biol. Chem. 271, 28509.
          Uhm, J.H., et al. 1996. Clin. Exp. Metastasis 14, 421.
          Product Information
          CAS number5144-89-8
          ATP CompetitiveN
          FormWhite to cream solid
          Hill FormulaC₁₂H₈N₂ · H₂O
          Chemical formulaC₁₂H₈N₂ · H₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMetalloprotease inhibitor
          Purity≥99% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSSF8437000
          Safety Information
          R PhraseR: 25-50/53

          Toxic if swallowed.
          Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
          S PhraseS: 45-60-61-37

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          This material and its container must be disposed of as hazardous waste.
          Avoid release to the environment. Refer to special instructions/safety data sheet.
          Wear suitable gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          516705

          References

          Reference overview
          Stix, B., et al. 2001. Am. J. Pathol. 159, 561.
          Bolzan, A.D., et al. 2000. Mutat. Res. 447, 221.
          Wang, Y., et al. 1999. J. Biol. Chem. 274, 33043.
          Harayama, T., et al. 1999. Jpn. J. Can. Res. 90, 942.
          Krane, S.M., et al. 1996. J. Biol. Chem. 271, 28509.
          Uhm, J.H., et al. 1996. Clin. Exp. Metastasis 14, 421.

          Brochure

          Title
          Protease and Phosphatase Inhibitor Cocktails Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-August-2018 JSW
          Synonyms1,10-Phenanthroline Monohydrate
          DescriptionA metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general matrix metalloproteinase inhibitor. Forms a red chelate with Fe2+ that absorbs maximally at 510 nm. Can be used as a photometric reagent for iron.
          FormWhite to cream solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5144-89-8
          RTECSSF8437000
          Chemical formulaC₁₂H₈N₂ · H₂O
          Structure formulaStructure formula
          Purity≥99% by titration
          SolubilityDMSO (100 mg/ml), ethanol (25 mg/ml), or H₂O (3 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Toxicity Toxic
          Merck USA index14, 7214
          ReferencesStix, B., et al. 2001. Am. J. Pathol. 159, 561.
          Bolzan, A.D., et al. 2000. Mutat. Res. 447, 221.
          Wang, Y., et al. 1999. J. Biol. Chem. 274, 33043.
          Harayama, T., et al. 1999. Jpn. J. Can. Res. 90, 942.
          Krane, S.M., et al. 1996. J. Biol. Chem. 271, 28509.
          Uhm, J.H., et al. 1996. Clin. Exp. Metastasis 14, 421.