533872 miR-122 Inhibitor, NSC5476 - CAS 5455-90-3 - Calbiochem

533872
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈HN₂O₂S 5455-90-3

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      5.33872.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable trans-decahydroquinolinylsulfonamide compound that acts as a potent, selective, and reversible inhibitor of miR-122 (EC50 = 600 nM in Huh7 cells transfected with psiCHECK-miR122 reporter plasmid). Induces a 1,250% increase in the relative luciferase signal that is indicative of strong miRNA-122 inhibition. Displays very little activity towards miR-21. Shown to down regulate the levels of mature miR-122 (by 72%) and the primary miR-122 (down to 3%). Shown to reduce hepatitis C virus (HCV) replication in Huh7 cells (47% reduction at 10 µM).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533872
          Brand Family Calbiochem®
          Synonyms6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, NSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor
          DescriptionmiR-122 Inhibitor, NSC5476
          References
          ReferencesYoung, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
          Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.
          Product Information
          CAS number5455-90-3
          FormWhite solid
          Hill FormulaC₁₈HN₂O₂S
          Chemical formulaC₁₈HN₂O₂S
          ReversibleY
          Applications
          Biological Information
          Primary TargetmiR-122
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          miR-122 Inhibitor, NSC5476 - CAS 5455-90-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Young, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
          Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2016 JSW
          Synonyms6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, NSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor
          DescriptionA cell-permeable trans-decahydroquinolinylsulfonamide compound that downregulates the liver-specific microRNA miR-122 level and pri-miR-122 production in Huh7 cells (by 72% & 93%, respectively; 10 µM for 48 h) without interaction with pre-miR-123 or affecting cellular miR-21 level. Selectively prevents miR-122-, but not miR-21-, mediated reporter transcription blockage (10 µM for 48 h) and suppresses HCV replication (by 53%; 10 µM inhibitor added 4 h post H77c/H77c/QR/KR/FV/SI RNA transfection for 48 h) in Huh7 cultures without affecting Huh7 proliferation.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5455-90-3
          Chemical formulaC₁₈HN₂O₂S
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYoung, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
          Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.