534347 hCNT2 Inhibitor

534347
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₂₄N₆O₄

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      5.34347.0001
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          Glass bottle 10 mg
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          Description
          OverviewAn aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na+-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC50 of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number534347
          Brand Family Calbiochem®
          Synonyms8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
          DescriptionhCNT2 Inhibitor
          References
          ReferencesTatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.
          Product Information
          FormPale yellow solid
          Hill FormulaC₂₃H₂₄N₆O₄
          Chemical formulaC₂₃H₂₄N₆O₄
          ReversibleY
          Applications
          Biological Information
          Primary TargethCNT2
          Primary Target IC<sub>50</sub>640 nM in COS-7 cells
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          hCNT2 Inhibitor SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-June-2016 JSW
          Synonyms8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
          DescriptionAn aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na+-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC50 of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₂₄N₆O₄
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.