324896 | eIF-2α Inhibitor II, Sal003 - CAS 301359-91-1 - Calbiochem

324896
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₅Cl₄N₃OS 301359-91-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324896-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.
          Catalogue Number324896
          Brand Family Calbiochem®
          Synonyms3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003
          References
          ReferencesRaven, J.F., et al. 2008. J. Biol. Chem. 283, 3097.
          Baltzis, D., et al. 2007. J. Biol. Chem. 282, 31675.
          Kazemi, S., et al. 2007. Mol. Biol. Cell 18, 3635.
          Costa-Mattioli, M., et al. 2007. Cell 129, 195.
          Robert, F., et al. 2006. Mol. Biol. Cell 17, 4632.
          Product Information
          CAS number301359-91-1
          FormOff-white solid
          Hill FormulaC₁₈H₁₅Cl₄N₃OS
          Chemical formulaC₁₈H₁₅Cl₄N₃OS
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324896

          References

          Reference overview
          Raven, J.F., et al. 2008. J. Biol. Chem. 283, 3097.
          Baltzis, D., et al. 2007. J. Biol. Chem. 282, 31675.
          Kazemi, S., et al. 2007. Mol. Biol. Cell 18, 3635.
          Costa-Mattioli, M., et al. 2007. Cell 129, 195.
          Robert, F., et al. 2006. Mol. Biol. Cell 17, 4632.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          Synonyms3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003
          DescriptionA cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number301359-91-1
          Chemical formulaC₁₈H₁₅Cl₄N₃OS
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesRaven, J.F., et al. 2008. J. Biol. Chem. 283, 3097.
          Baltzis, D., et al. 2007. J. Biol. Chem. 282, 31675.
          Kazemi, S., et al. 2007. Mol. Biol. Cell 18, 3635.
          Costa-Mattioli, M., et al. 2007. Cell 129, 195.
          Robert, F., et al. 2006. Mol. Biol. Cell 17, 4632.