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324895 | eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

324895
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₇Cl₃N₄OS 304475-63-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324895-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 = ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 = ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. Also available as a 50 mM solution in DMSO (Cat. No. 324897).
          Catalogue Number324895
          Brand Family Calbiochem®
          SynonymsSal
          References
          ReferencesBoyce, M., et al. 2005. Science 307, 935.
          Product Information
          CAS number304475-63-6
          ATP CompetitiveN
          FormBeige solid
          Hill FormulaC₂₁H₁₇Cl₃N₄OS
          Chemical formulaC₂₁H₁₇Cl₃N₄OS
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetelF-2α
          Primary Target IC<sub>50</sub>3 µM preventing HSV replication both in Vero cells.
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324895

          References

          Reference overview
          Boyce, M., et al. 2005. Science 307, 935.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Protease and Phosphatase Inhibitor Cocktails Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-September-2013 JSW
          SynonymsSal
          DescriptionA cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380)). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number304475-63-6
          Chemical formulaC₂₁H₁₇Cl₃N₄OS
          Structure formula
          Purity≥90% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBoyce, M., et al. 2005. Science 307, 935.