324516 | eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem

324516
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₅N₅O₃ 142557-61-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324516-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
          Catalogue Number324516
          Brand Family Calbiochem®
          Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
          References
          ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
          Product Information
          CAS number142557-61-7
          FormOff-white powder
          Hill FormulaC₁₃H₁₅N₅O₃
          Chemical formulaC₁₃H₁₅N₅O₃
          Structure formula ImageStructure formula Image
          Applications
          ApplicationeEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324516

          References

          Reference overview
          Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-July-2012 JSW
          Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
          DescriptionA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number142557-61-7
          Chemical formulaC₁₃H₁₅N₅O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (2.5 mg/ml; clear, colorless solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.