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324515 | eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem

324515
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₄₅IN₂ 278603-08-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324515-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
          Catalogue Number324515
          Brand Family Calbiochem®
          Synonyms1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
          References
          ReferencesArora, S., et al. 2004. Mol. Pharmacol. 66, 460.
          Arora, S., et al. 2003. Cancer Res. 63, 6894.
          Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
          Product Information
          CAS number278603-08-0
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₇H₄₅IN₂
          Chemical formulaC₂₇H₄₅IN₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetBacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
          Primary Target IC<sub>50</sub>60 nM against the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
          Purity≥95% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324515

          References

          Reference overview
          Arora, S., et al. 2004. Mol. Pharmacol. 66, 460.
          Arora, S., et al. 2003. Cancer Res. 63, 6894.
          Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-June-2009 RFH
          Synonyms1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
          DescriptionA cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number278603-08-0
          Chemical formulaC₂₇H₄₅IN₂
          Structure formula
          Purity≥95% by NMR
          SolubilityDMSO (20 mg/ml) or 70% Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesArora, S., et al. 2004. Mol. Pharmacol. 66, 460.
          Arora, S., et al. 2003. Cancer Res. 63, 6894.
          Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.