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23-027 | b-catenin Protein, activated, 10 µg

10 µg  
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      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesCascade Component
      EA Human Substrate
      Catalogue Number23-027
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionb-catenin Protein, activated, 10 µg
      OverviewN-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.
      Alternate Names
      • Catenin beta-1
      Background Informationβ-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.
      Product Information
      ApplicationActivated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
      Key Applications
      • Enzyme Assay
      Biological Information
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      #946;-catenin, activated - D11DP018NA D11DP018NA
      b-catenin, activated - D11DP018N-A D11DP018N-A
      β-catenin, activated - D11DP018NB D11DP018NB


      Reference overviewPub Med ID
      β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.
      Schade, Babette, et al.
      Cancer Res., 73: 4474-87 (2013) 2013

      Show Abstract
      23720052 23720052

      Technical Info

      Detecting Substrate Ubiquitination by the E3 Ligase, XIAP, Using Quantitative Assays

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      23-027M b-catenin Protein, activated, 250 µg Show Pricing & Availability

      Product Families


      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Ubiquitination Substrates
      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitination Substrates