691550 Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem

691550
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₄H₃₂N₄O₄Zn 15442-64-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      691550-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.
          Catalogue Number691550
          Brand Family Calbiochem®
          SynonymsZnPP-9
          References
          ReferencesWolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
          Bing, O., et al. 1995. NeuroReport 6, 1369.
          Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
          Kadoya, C., et al. 1995. Stroke 26, 1035.
          Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
          Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
          Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
          Zhuo, M., et al. 1993. Science 260, 1946.
          Product Information
          CAS number15442-64-5
          ATP CompetitiveN
          FormDark red solid
          Hill FormulaC₃₄H₃₂N₄O₄Zn
          Chemical formulaC₃₄H₃₂N₄O₄Zn
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetheme oxygenase
          Primary Target IC<sub>50</sub> 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          691550

          References

          Reference overview
          Wolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
          Bing, O., et al. 1995. NeuroReport 6, 1369.
          Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
          Kadoya, C., et al. 1995. Stroke 26, 1035.
          Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
          Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
          Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
          Zhuo, M., et al. 1993. Science 260, 1946.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-September-2008 RFH
          SynonymsZnPP-9
          DescriptionA potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 0.8 µM, 4.0 µM, and 5.0 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron deficient erythropoiesis. Does not cross the blood-brain barrier.
          FormDark red solid
          CAS number15442-64-5
          Chemical formulaC₃₄H₃₂N₄O₄Zn
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMF or Pyridine
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesWolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
          Bing, O., et al. 1995. NeuroReport 6, 1369.
          Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
          Kadoya, C., et al. 1995. Stroke 26, 1035.
          Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
          Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
          Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
          Zhuo, M., et al. 1993. Science 260, 1946.