682160 Xestospongin C, Xestospongia sp. - Calbiochem

682160
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₈H₅₀N₂O₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      682160-10UG
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          Plastic ampoule 10 μg
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          Description
          OverviewAn oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the endoplasmic reticulum stores in a reversible manner.
          Catalogue Number682160
          Brand Family Calbiochem®
          SynonymsXeC
          References
          ReferencesOka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
          Gafni, J., et al. 1997. Neuron 19, 723.
          Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
          Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
          Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
          Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
          Product Information
          ATP CompetitiveN
          FormWhite to off-white film
          Hill FormulaC₂₈H₅₀N₂O₂
          Chemical formulaC₂₈H₅₀N₂O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationXestospongin C, Xestospongia sp. CAS 88903-69-9, is a highly potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM).
          Biological Information
          Primary TargetIP3-mediated Ca2+ release
          Primary Target IC<sub>50</sub>358 nM in blocking IP3-mediated Ca2+ release
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-24/25-36/37/39-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Xestospongin C, Xestospongia sp. - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Xestospongin C, Xestospongia sp. - Calbiochem Certificates of Analysis

          TitleLot Number
          682160

          References

          Reference overview
          Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
          Gafni, J., et al. 1997. Neuron 19, 723.
          Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
          Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
          Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
          Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.

          Citations

          Title
        • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
        • Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-January-2019 JSW
          SynonymsXeC
          DescriptionA macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the ER stores in a reversible manner.
          FormWhite to off-white film
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₈H₅₀N₂O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (1 mg/ml), Ethanol (1 mg/ml), or Methanol (1 mg/ml). Sonication may be required to achieve complete solubilization.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesOka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
          Gafni, J., et al. 1997. Neuron 19, 723.
          Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
          Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
          Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
          Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
          Citation
        • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
        • Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.
        • Related Products & Applications

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators