681671 Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem

681671
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₁₈N₄O₂S₃ 686770-61-6

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      681671-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
          Catalogue Number681671
          Brand Family Calbiochem®
          SynonymsInhibitor of Wnt Production-2, Porcn Inhibitor I, Wnt Pathway Inhibitor II
          References
          ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
          Product Information
          CAS number686770-61-6
          FormOff-white solid
          Hill FormulaC₂₂H₁₈N₄O₂S₃
          Chemical formulaC₂₂H₁₈N₄O₂S₃
          Applications
          ApplicationWnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-24/25-36-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          681671

          References

          Reference overview
          Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-February-2014 JSW
          SynonymsInhibitor of Wnt Production-2, Porcn Inhibitor I, Wnt Pathway Inhibitor II
          DescriptionA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number686770-61-6
          Chemical formulaC₂₂H₁₈N₄O₂S₃
          Purity≥97% by HPLC
          SolubilityDMSO (2.5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.