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681525 | Wiskostatin - CAS 253449-04-6 - Calbiochem

681525
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₈Br₂N₂O 253449-04-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      681525-1MG
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          Glass bottle 1 mg
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          681525-5MG
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              Glass bottle 5 mg
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              Description
              OverviewA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
              Catalogue Number681525
              Brand Family Calbiochem®
              References
              ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
              Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
              Product Information
              CAS number253449-04-6
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₁₇H₁₈Br₂N₂O
              Chemical formulaC₁₇H₁₈Br₂N₂O
              ReversibleY
              Structure formula Image
              Applications
              Biological Information
              Primary TargetN-WASP (neural Wiskott Aldrich syndrome protein)
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              681525

              References

              Reference overview
              Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
              Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision02-April-2008 RFH
              DescriptionA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of neural Wiskott Aldrich Syndrome protein (N-WASP). Reported to bind to N-WASP, stabilize the auto-inhibited conformation, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number253449-04-6
              Chemical formulaC₁₇H₁₈Br₂N₂O
              Structure formula
              Purity≥95% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
              Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.