A part of MilliporeSigma

681625 | W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem

681625
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₂₂N₂O₂S · HCl 61714-25-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      681625-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).
          Catalogue Number681625
          Brand Family Calbiochem®
          SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
          References
          ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
          Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
          Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
          Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
          Product Information
          CAS number61714-25-8
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₁₆H₂₂N₂O₂S · HCl
          Chemical formulaC₁₆H₂₂N₂O₂S · HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetMyosin light chain kinase (Mlck)
          Primary Target IC<sub>50</sub>230 µM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          681625

          References

          Reference overview
          Tanaka, T., et al. 1983. Pharmacol. 26, 249.
          Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
          Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
          Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-January-2010 RFH
          SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
          DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).
          FormCrystalline solid
          CAS number61714-25-8
          Chemical formulaC₁₆H₂₂N₂O₂S · HCl
          Structure formula
          Purity≥98% by NMR
          SolubilityDMSO or H₂O
          Storage +2°C to +8°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
          Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
          Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
          Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

          Related Products & Applications

          Related Products

          Catalog Number Description  
          681629 W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem Show Pricing & Availability
          681635 W-12, Hydrochloride - CAS 89108-46-3 - Calbiochem Show Pricing & Availability
          681636 W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem Show Pricing & Availability

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors