504373 | Vicriviroc Malate - CAS 541503-81-5 - Calbiochem

504373
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₃₈F₃N₅O₂·C₄H₆O₅ 541503-81-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04373.0001
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          Glass bottle 5 mg
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          Description
          OverviewA potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
          Catalogue Number504373
          Brand Family Calbiochem®
          Synonyms(4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
          References
          ReferencesBerro, R., et al. 2012. Virology 427, 158.
          Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
          Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.
          Product Information
          CAS number541503-81-5
          FormBeige powder
          Hill FormulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
          Chemical formulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCCR5
          Primary Target IC<sub>50</sub>0.91 nM
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Berro, R., et al. 2012. Virology 427, 158.
          Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
          Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-August-2013 JSW
          Synonyms(4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
          DescriptionA potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
          FormBeige powder
          CAS number541503-81-5
          Chemical formulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBerro, R., et al. 2012. Virology 427, 158.
          Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
          Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.