05-23-2101 | Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem

05-23-2101
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄₇H₂₃₈N₄₄O₄₂S 40077-57-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      05-23-2101-0.5MG
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          Plastic ampoule .5 mg
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          05-23-2101-1MG
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              Glass bottle 1 mg
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              Description
              OverviewActs as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Inhibits the growth of human small-cell lung carcinoma (SCLC) both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC. Nitric oxide stimulates the release of this peptide.
              Catalogue Number05-23-2101
              Brand Family Calbiochem®
              SynonymsVIP
              References
              ReferencesMaruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
              Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
              Grider, J.R. 1993. Am. J. Physiol. 264, G334.
              Product Information
              CAS number40077-57-4
              ATP CompetitiveN
              FormWhite to off-white lyophilized solid
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₁₄₇H₂₃₈N₄₄O₄₂S
              Chemical formulaC₁₄₇H₂₃₈N₄₄O₄₂S
              Hygroscopic Hygroscopic
              ReversibleN
              Sold on the basis of peptide contentY
              Applications
              Biological Information
              Primary TargetMitogenic factor for embryonic neurons
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide ContentY
              Peptide SequenceH-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 20/21/22

              Harmful by inhalation, in contact with skin and if swallowed.
              S PhraseS: 36

              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              05-23-2101

              References

              Reference overview
              Maruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
              Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
              Grider, J.R. 1993. Am. J. Physiol. 264, G334.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision18-September-2008 RFH
              SynonymsVIP
              DescriptionActs as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Nitric oxide stimulates the release of this peptide. Inhibits human small-cell lung carcinoma (SCLC) in nude mice both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC.
              FormWhite to off-white lyophilized solid
              FormulationSupplied as a trifluoroacetate salt.
              CAS number40077-57-4
              Chemical formulaC₁₄₇H₂₃₈N₄₄O₄₂S
              Peptide SequenceH-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
              Purity≥95% by HPLC
              Solubility5% Acetic acid (1 mg/ml)
              Storage -20°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Harmful
              ReferencesMaruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
              Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
              Grider, J.R. 1993. Am. J. Physiol. 264, G334.