676380 Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem

676380
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₅O₂Na 1069-66-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      676380-5GM
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          Plastic ampoule 5 gm
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          Description
          OverviewA cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
          Catalogue Number676380
          Brand Family Calbiochem®
          Synonyms2-Propylpentanoic Acid, Na
          References
          ReferencesGottlicher, M., et al. 2001. EMBO J. 20, 6969.
          Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
          Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
          Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
          Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
          Chen, G., et al. 1999. J. Neurochem. 72, 1327.
          Product Information
          CAS number1069-66-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₈H₁₅O₂Na
          Chemical formulaC₈H₁₅O₂Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationValproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines.
          Biological Information
          Primary TargetHDAC1
          Primary Target IC<sub>50</sub>400 µM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYV7876000
          Safety Information
          R PhraseR: 20/21/22-36/37/38-61

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause harm to the unborn child.
          S PhraseS: 3/7/9-22-36/37/39-45

          Keep container tightly closed, in a cool well ventilated place.
          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          676380

          References

          Reference overview
          Gottlicher, M., et al. 2001. EMBO J. 20, 6969.
          Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
          Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
          Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
          Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
          Chen, G., et al. 1999. J. Neurochem. 72, 1327.

          Technical Info

          Title
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2014 JSW
          Synonyms2-Propylpentanoic Acid, Na
          DescriptionA cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1069-66-5
          RTECSYV7876000
          Chemical formulaC₈H₁₅O₂Na
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (50 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 9913
          ReferencesGottlicher, M., et al. 2001. EMBO J. 20, 6969.
          Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
          Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
          Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
          Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
          Chen, G., et al. 1999. J. Neurochem. 72, 1327.