676492 VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

676492
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₈N₂O 163655-37-6

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      676492-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.
          Catalogue Number676492
          Brand Family Calbiochem®
          SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
          References
          ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
          Product Information
          CAS number163655-37-6
          ATP CompetitiveY
          DeclarationNot available for sale in Germany.
          FormRed solid
          Hill FormulaC₂₁H₁₈N₂O
          Chemical formulaC₂₁H₁₈N₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationVEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.
          Biological Information
          Primary TargetVEGF receptor tyrosine kinase
          Primary Target IC<sub>50</sub>At low concentration (≤5 µM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells.
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          676492

          References

          Reference overview
          Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
          DescriptionA cell-permeable, 3-substituted, indolin-2-one compound that acts as a reversible and ATP-competitive inhibitor of VEGF receptor tyrosine kinase. At low concentrations (5 µM), reported to specifically block VEGF-C and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. Reported to partially block VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential inhibition may be useful for controlling lymphangiogenesis-dependent tumor metastasis and could, therefore, be of clinical significance for cancer therapy studies.
          FormRed solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number163655-37-6
          Chemical formulaC₂₁H₁₈N₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530