676493 VEGF Inhibitor, Flt₂₋₁₁ - Calbiochem

676493
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₆₁H₁₀₄N₁₄O₁₅

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      676493-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewAn 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is shown to inhibit angiogenesis in chick chorioallantoic membrane and inhibits VEGF-induced vascular permeability. Neither binds to vascular endothelial growth factor (VEGF) nor inhibits its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.
          Catalogue Number676493
          Brand Family Calbiochem®
          SynonymsNITVTLKKFPL, VEGFR Tyrosine Kinase Inhibitor X, VEGFR1 Kinase Inhibitor I
          References
          ReferencesTan, D.C., et al. 2001. FEBS Lett. 494, 150.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patent 6,200,954.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₁H₁₀₄N₁₄O₁₅
          Chemical formulaC₆₁H₁₀₄N₁₄O₁₅
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetVEGF
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Asn-Ile-Thr-Val-Thr-Leu-Lys-Lys-Phe-Pro-Leu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          VEGF Inhibitor, Flt₂₋₁₁ - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          VEGF Inhibitor, Flt₂₋₁₁ - Calbiochem Certificates of Analysis

          TitleLot Number
          676493

          References

          Reference overview
          Tan, D.C., et al. 2001. FEBS Lett. 494, 150.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-September-2008 RFH
          SynonymsNITVTLKKFPL, VEGFR Tyrosine Kinase Inhibitor X, VEGFR1 Kinase Inhibitor I
          DescriptionAn 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is reported to inhibit angiogenesis in chick chorioallantoic membrane and VEGF-induced vascular permeability. Does not bind to vascular endothelial growth factor (VEGF) nor inhibit its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₆₁H₁₀₄N₁₄O₁₅
          Peptide SequenceH-Asn-Ile-Thr-Val-Thr-Leu-Lys-Lys-Phe-Pro-Leu-OH
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or acetonitrile (20%)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTan, D.C., et al. 2001. FEBS Lett. 494, 150.