672999 V-ATPase Inhibitor, KM91104 - Calbiochem

672999
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₁₂N₂O₄

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      672999-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC50 of 2.3 µM), in vitro. It is also shown to inhibit osteoclast resorption (IC50 of 1.2 µM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.
          Catalogue Number672999
          Brand Family Calbiochem®
          SynonymsH+-ATPase Inhibitor
          References
          ReferencesKartner, N., et al. 2010. J. Biol. Chem. 285, 37476.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₄H₁₂N₂O₄
          Chemical formulaC₁₄H₁₂N₂O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity>98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          V-ATPase Inhibitor, KM91104 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          V-ATPase Inhibitor, KM91104 - Calbiochem Certificates of Analysis

          TitleLot Number
          672999

          References

          Reference overview
          Kartner, N., et al. 2010. J. Biol. Chem. 285, 37476.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2015 JSW
          SynonymsH+-ATPase Inhibitor
          DescriptionA cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC50 of 2.3 µM), in vitro. It is also shown to inhibit osteoclast resorption (IC50 of 1.2 µM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄H₁₂N₂O₄
          Structure formulaStructure formula
          Purity>98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKartner, N., et al. 2010. J. Biol. Chem. 285, 37476.