662105 Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem

662105
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₁₃N₃O₇ • 3H₂O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      662105-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
          Catalogue Number662105
          Brand Family Calbiochem®
          Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
          References
          ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.
          Product Information
          FormDark purple solid
          Hill FormulaC₁₇H₁₃N₃O₇ • 3H₂O
          Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
          Structure formula ImageStructure formula Image
          Applications
          ApplicationUbiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).
          Biological Information
          Purity≥90% by HPLC (sum of two isomers)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-24/25-36-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem Certificates of Analysis

          TitleLot Number
          662105

          References

          Reference overview
          Yang, Y., et al. 2007. Cancer Res. 67, 9472.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-March-2009 RFH
          Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
          DescriptionA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
          FormDark purple solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
          Structure formulaStructure formula
          Purity≥90% by HPLC (sum of two isomers)
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
          Toxicity Irritant
          ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.